KMID : 0361920100400020106
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Korean Journal of Orthodontics 2010 Volume.40 No. 2 p.106 ~ p.114
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Stimulation of bone formation by direct electrical current in an orthopedically expanded suture in the rat
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Uysal Tancan
Amasyali Mihri Olmez Huseyin Karslioglu Yildirim Gunhan Omer
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Abstract
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Objective: The aim of this experimental study was to evaluate the effects of direct electrical current stimulation (DECS) on bone regeneration in response to an expansion of the inter-premaxillary suture in the rat.
Methods: Sixteen 50 - 60 days old Wistar male rats were separated into two equal groups (control and experimental). Both groups were subjected to expansion, and 30-gram of force was applied to the maxillary incisors with helical-spring. In the experimental group, two metallic-screws were placed at lateral parts of the maxillary segments. Electrodes were connected to the screws. The device was activated with current adjustment to measure 10 ¥ìA continuously and the current was monitored daily during the expansion and early-retention phase. Bone regeneration in the sutural area was histomorphometrically evaluated including new-bone area (¥ìm2), bone perimeter (¥ìm), feret¡¯s diameter (¥ìm) and newly formed bone (%) parameters. Kruskal-Wallis rank and Mann-Whitney U tests were used for statistical evaluation at p < 0.05 level.
Results: Statistical analysis showed significant differences between groups for all investigated histomorphometric parameters. New bone area (p = 0.002), bone perimeter (p = 0.004), feret¡¯s diameter (p = 0.002) and newly formed bone percentage (p = 0.002) measurements were significantly higher in the experimental group than the control group. Bone histomorphometric measurements revealed that bone architecture in the DECS group was improved.
Conclusions: The application of DECS to an orthopedically expanded inter-premaxillary suture area during the early retention phase stimulated the formation of new bone.
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KEYWORD
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Electric stimulation, Maxillary expansion, Image analysis, Rats
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